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The Chicago Center for Vision Research is committed to advancing new ocular therapies, supporting education of future glaucoma specialists, and expanding public awareness for glaucoma.

 

Chicago Center for Vision Research

The Chicago Center for Vision Research is a not-for-profit organization started in 1998 by Drs. Theodore Krupin, Lisa F. Rosenberg, and Jon M. Ruderman to support ophthalmology research and education. The Chicago Center for Vision Research is committed to advancing new ocular therapies, supporting education of future glaucoma specialists, and expanding public awareness for glaucoma. Activities of Chicago Center for Vision Research are sponsored by generous contributions from patients and corporate sponsors. All donations go directly to research and education

Researching New Therapies

Current Chicago Center for Vision Research activities include:

1. Participating in a nationwide study investigating a new oral medication that may protect the optic nerve from glaucoma damage, independent of lowering eye pressure. This exciting study may provide a new therapy to prevent loss of vision from glaucoma.
2. Directing an ongoing study involving twelve eye centers around the country that evaluates the treatment of glaucoma patients with normal eye pressures compared to most other patients who have elevated eye pressure. This study will provide important clinical information on the management of low-pressure glaucoma patients and possible methods to prevent further loss of vision.
3. Pioneering investigations on a new, original computer program to detect visual field defects using the internet. The aim is to create a screening test that can be taken in the home to detect the presence of vision loss.
4. Involved in studies comparing different combinations of glaucoma medications. The aim is to determine the interactions of the medications and the best treatment regimen for patients.
5. Pioneering studies on a new laser system to treat open-angle glaucoma. This new laser system offers the ability to lower eye pressure more effectively than lasers currently used. This innovative laser causes less tissue damage and may be repeated if the need arises to produce long-term lowering of eye pressure.
6. Studyingthe effects of new medicines for general medical problems (i.e., gastrointestinal disorders, depression, high blood pressure, and elevated cholesterol and blood lipids) on the eye.
7. Participating in nationwide studies investigating new drugs to lower eye pressure. These medications offer expanded therapies to treat glaucoma patients.

The Chicago Center for Vision Research and Drs. Krupin, Rosenberg, and Ruderman have performed clinical research for the purpose of discovering, developing, and verifying knowledge relating to the causes, diagnoses, treatment, and control of eye disease, primarily in the area of glaucoma. A representative list of recent publications follows:

Ritch R, Krupin T, Henry C, Kurata F: Oral imipramine and acute angle closure glaucoma. Arch Ophthalmol 112:67-8, 1994.
Wong PC, Ruderman JM, Krupin T, Goldenfeld M, Rosenberg LF, Shields MB, Ritch R, Liebmann JM, Gieser DK: 5-fluorouracil after primary combined filtration surgery. Am J Ophthalmol, 117:149-154, 1994.
The Krupin Eye Valve Filtering Surgery Study Group: Krupin Eye Valve With Disk For Filtration Surgery. Ophthalmology, 101:651-658, 1994.
Goldenfeld M, Krupin T, Ruderman JM, Wong PC, Rosenberg LF, Ritch R, Liebmann JM, Gieser DK: 5-fluorouracil in initial trabeculectomy: A prospective, randomized, multicenter study. Ophthalmology, 101:1024-1029, 1994.
Siegfried CJ, Rosenberg LF, Krupin T, Jampol LM: Hypotony after glaucoma filtration surgery: mechanisms and incidence. J Glaucoma, 4:63-69, 1994.
Rosenberg LF, Burchfield JC, Krupin T, Bock CJ Jr, Goldenfeld M, O'Grady RB: Cat model for intraocular pressure reduction after transscleral Nd:YAG cyclophotocoagulation. Curr Eye Res 14:255-261, 1995.
Krupin T, Rosenberg LF, Sandridge AL, Bock CJ Jr, Berman A, Ruderman JM: Effects of topical k-strophanthin on aqueous humor and corneal dynamics. J Glaucoma 4:327-333, 1995.
Rosenberg LF, Krupin T, Ruderman J, McDaniel DL, Siegfried C, Karalekas DP, Grewal RK, Gieser DK, Williams R: Apraclonidine and anterior segment laser surgery: Comparison of 0.5% versus 1.0% for prevention of postoperative intraocular pressure rise. Ophthalmology 102:1312-1318, 1995.
Siegfried CJ, Grewal RK, Karalekas DP, Rosenberg LF, Krupin T: Marked pressure rise complicating intrableb injection of autologous blood. Arch Ophthalmol 114:492-3, 1996.
Meyer MA, Hernandez RH III, Krupin T, Rosenberg LF, Ruderman JM: Lens choice in complicated cataract extraction in glaucomatous eyes. J Glaucoma 6:56-61, 1997.
Wyse TB, Talluto DM, Krupin T, Rosenberg LF, Ruderman JM: Topical prostaglandins for glaucoma therapy. J Glaucoma 6:180-187, 1997.
Talluto DM, Wyse TB, Krupin T: Topical carbonic anhydrase inhibitors. Curr Opin Ophthalmol 8:2-6, 1997.
Wyse TB, Talluto D, Krupin T, Rosenberg LF, Ruderman JM: Lantoprost: A review. Sem Ophthalmol 12:134-142, 1997.
Rosenberg LF, Krupin T, Tang Li-Qi, Hong PH, Ruderman JM: Additivity of systemic acetazolamide and topical dorzolamide for reduction of intraocular pressure and aqueous humor production. Ophthalmology 105:88-93, 1998.
Wyse T, Meyer M, Ruderman JM, Krupin T, Talluto D, Hernandez R, Rosenberg LF: Combined trabeculectomy and phacoemulsification: A one-site vs two-site approach. Am J Ophthalmol 125:334-339, 1998.
Borisuth NSC, Phillips B, Krupin T: The risk profile of glaucoma filtration surgery. Curr Opin Ophthalmol 10:112-117, 1999.
Heffelfinger BL, Berman MN, Krupin T, Rosenberg LF, Ruderman JM: Surgical management of coexisting glaucoma and cataract. Ophthalmol Clinics N Am 13:545-552, 2000.
Drs. Krupin, Rosenberg, and Ruderman are authors of chapters in textbooks relating to glaucoma. Drs. Krupin and Rosenberg are editors of the following recent textbooks:
The Glaucomas. Second Edition (volumes I, II, III). Edited by Robert Ritch, M. Bruce Shields, Theodore Krupin. CV Mosby Co, 1996.
Atlas of Complications in Ophthalmic Surgery. Second Edition. Edited by Theodore Krupin, Allan E. Kolker, Lisa F. Rosenberg. Mosby-Year Book Europe, 1999.

Supporting Education of Future Glaucoma Specialists

The Chicago Center for Vision Research promotes training of glaucoma specialists by sponsoring glaucoma fellowships, research training of ophthalmology residents at Northwestern University, and medical students. During their careers, Drs. Krupin, Rosenberg, and Ruderman have trained more than 50 glaucoma fellows. These glaucoma fellows are now practicing around the world - caring for patients, performing new research, and educating other medical professionals. Providing first-rate glaucoma fellowship training is important to help ensure quality care is more accessible to people everywhere.

Our current glaucoma fellows are actively involved in our research activities.

Dr. Darin Sakiyalak received her medical degree and ophthalmology training at Mahidol University, Bangkok, Thailand, where she is a junior instructor. Last year she was a fellow at University Hospital of Cleveland. Her husband is also a physician who is currently a cardiovascular fellow at Loyola University. Darin recently attended the Inaugural meeting of the South-East Asian Glaucoma Interest Group in Bangkok where Dr. Krupin was an invited speaker.

Dr. John Yang received his medical degree and ophthalmology training at Northwestern University. He is the major developer of the internet testing of visual fields. John’s younger sister Renee is a fourth medical student who recently completed a three month research elective in our office

Creating Public Awareness

The key factor in preserving vision from glaucoma is early detection and treatment. Because glaucoma usually develops slowly, patients are often unaware that they are affected until they have noticed vision loss. The Chicago Center for Vision Research actively participates within national organizations to help educate the public through lectures, symposia, eye screenings, and health fairs. These national organizations include The Glaucoma Foundation of New York, The Glaucoma Foundation of San Francisco, Prevent Blindness America, the American Glaucoma Society, and the American Academy of Ophthalmology

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